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In contrast, the gdh3 / gdh3 mutant showed a higher concentration of ATP, NAD + , and NADH, but not NADP + or NADPH, when incubated in proline medium when compared to the wild-type strain (Figs 7 and 8)
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Importantly, the hallucinogenic drug ibogaine and its derivative 18-methoxycoronaridine (18-MC), an inhibitor of acetylcholine signaling, modulate the activity of MHb neurons, and this action facilitates the abstinence in some OUD patients
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