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This change also reflects potential considerations regarding tolerability, clinical outcomes, and affordability
Compared with GLP-1 alone, dual agonism may provide: greater appetite reduction for some patients improved insulin sensitivity additional metabolic benefits Clinical trials demonstrated substantial weight loss in many patients using tirzepatide for obesity management
Bian and colleagues aimed to evaluate this association in a retrospective cohort study that followed a target trial emulation design
Endogenous GLP-1 has several functions, including triggering insulin release from the pancreas, as well as decreasing appetite and digestion, and this drug class mimics the GLP-1 hormone
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