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While multiple subtypes have been described, dopamine cell bodies can be roughly divided between the substantia nigra pars compacta (SNc), which projects through the nigrostriatal pathway and is necessary for the initiation of voluntary movement, and the ventral tegmental area (VTA), which projects widely through the mesocorticolimbic pathway to regulate cognitive, motivational, and affective behaviors (Schultz, 2002

Endocrinol, Diabetes Metab

For patients who want to avoid needles, are budget-conscious but open to compounded medication, and want a fast, clinically supervised route into GLP-1 therapy without insurance hassles, Embody GLP-1 is worth serious consideration

The FDA cleared orforglipron for chronic weight management in adults with obesity, or overweight with at least one weight-related comorbidity, based on the ATTAIN clinical program which showed placebo-adjusted weight loss of 7.5% to 11.2% in non-diabetics (ATTAIN-1) and 5.1% to 9.6% in diabetics at different doses, along with the expected glycaemic benefits (ATTAIN-2)