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By extending and amplifying the GLP-1 signal, semaglutide helps slow gastric emptying, reduce appetite, and improve insulin response

Acute kidney injury has occurred, often in the context of severe dehydration from gastrointestinal side effects, emphasising the importance of maintaining adequate hydration

doi: 10.1016/j.cell.2016.05.011 19 AndersenDBGrunddalKVPedersenJKuhreRELundMLHolstJJet al

The estimated treatment difference was 8.03%, and higher than the weight change difference in the non-bariatric patients treated with liraglutide, which had been reported as 4.8% in a recent systematic review and meta-analysis of randomized controlled trials [50]