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GLP-1RA could not only facilitate the M2 polarization of microglia through both direct and indirect pathways, but also modulate the quantity and function of T cell subtypes, including CD4, CD8, and regulatory T cells, resulting into the inhibition of inflammatory responses and the promotion of neuronal regeneration through interleukin-10 secretion
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Both have changed what is possible with non-surgical weight loss, and there is now head-to-head clinical data showing how they stack up against each other
Time will tell whether or not GLP-1s are curative for OSA, likely in some cases, but unlikely in most
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