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The explanation for the gap is not that the trials were wrong
Meyer CW, Ootsuka Y, Romanovsky AA
Side Effects: Similar Class Effects, Mild to Moderate Most Common Issues (Both Drugs) Nausea Diarrhea Vomiting Reduced appetite Constipation Most symptoms appear during dose escalation and taper off over time
29 Mast Cell Stabilizers Research suggests increased levels of mast cells and their activation and release of intracellular molecules (including histamine, tryptase and other proteases, serotonin, nitric oxide, and numerous cytokines and chemokines) may play a role in the pathogenesis of IBS
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