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Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
This is higher than other GLP-1s, which had discontinuation rates of 6.1% (tirzepatide), 8.0% (semaglutide) and 10.3% (orforglipron)
People who experience gastro-paresis after taking Ozempic may or may not see their symptoms resolve if they stop taking the drug
The SELECT data simply quantifies the long-term clinical benefit of those early changes sustained over time
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