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In fact, the clinical diagnosis of PD requires the presence of bradykinesia accompanied by at least one other motor symptom, such as resting tremor, muscle rigidity, or postural instability
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For instance, a 2017 review showed that taking L-carnitine for 3 days had no effect on markers of brain function including reaction time, vigilance, immediate memory, and delayed recall in young adults without cognitive impairment
We believe these results are due to the nanomolar agonist concentrations applied, which were selected to simulate receptor activation levels similar to those that might occur physiologically, even if not precisely matching actual in vivo concentrations
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