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Apart from glycolysis in cancer cells, glutaminolysis (i.e., a series of biochemical reactions by which glutamine is lysed to glutamate) is another main pillar for energy production, including the conversion of glutamine to -ketoglutarate (KG), reaction steps of the citric acid cycle and malate aspartate shuttle, and the conversion of malate to pyruvate and lactate

When NNMT activity is high, NAD+ is depleted, metabolic rate slows, and fat accumulation increases

second, as a substrate for the production of hydrogen sulphide (H 2 S), which feeds the mitochondrial electron transfer chain and mediates per-sulphidation of ATPase and glycolytic enzymes, thereby stimulating cellular bioenergetics

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