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The implications are significant: these results raise the possibility that semaglutide may have insufficient central target engagement at the doses used, that the pharmacodynamic effect on AD-relevant pathways may be inadequate, or that targeting metabolic and inflammatory pathways may represent a fundamental limitation when applied to established amyloid-driven Alzheimers disease
Changing the conversation around obesity is an important step toward reducing stigma and improving patient outcomes
Semaglutide can be taken long-term under medical supervision
doi: 10.1016/j.josat.2023.209244 5 JhanjeeS
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