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The more serious gastrointestinal effects such as occult blood loss, gastrointestinal hemorrhage, ulcer and pancreatitis, are uncommon

This mechanism is central to both its appetite-suppressing effects and its GI side effects

However, in some cases, it can signal something more serious

Why GLP-1 Medications Are Gaining Attention GLP-1s (glucagon-like peptide-1 receptor agonists) help regulate appetite and blood sugar by: Reducing hunger Enhancing satiety Improving insulin secretion and slowing gastric emptying Reducing food cravings and food noise My role as a dietitian in GLP-1 use As a registered dietitian and nutritionist, I work with many clients taking Ozempic, Wegovy, Saxenda, and Mounjaro [For a list of the GLP-1 medications, see Figure 1 of this article]