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Pardieu, B
Generally speaking, it ranks among the most prevalent oral diseases, obviously impacting individual oral health and quality of life ( Oxidative stress refers to the phenomenon where excessive production of oxygen free radicals and other oxidants in the cellular and extracellular environment overwhelms the bodys antioxidant defense systems, which leads to cellular functional damage (Wang et al., 2017a), (Wang et al., 2017a), ( In the management of periodontitis, antioxidant therapy has appeared as a potential treatment strategy garnering wide attention
As a consequence, this triggers the generation of lipid peroxides, such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), which are extremely toxic to the cell because they initiate a newly characterized form of cell death termed ferroptosis (27), which is a key phenomenon in the pathogenesis of neurodegenerative diseases, such as Parkinsons disease (PD) (28)
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