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102 Furthermore, electron-microscopy observations have indicated that JS-K induces autophagic death in cells
p = 0.0003) and placebo (ETD: 3.8 kg
This oxidant stress causes activation of a MAP kinase cascade in the cytosol ultimately leading to phosphorylation of c-jun N-terminal kinase (P-JNK), translocation of P-JNK to the mitochondria [34], and binding to the anchor protein Sab [35] for amplification of the mitochondrial oxidant stress and peroxynitrite formation in the mitochondrial matrix [33, 36]
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