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More detailed body scans in clinical trials show that a fraction of the weight lost (a few percent) is from lean tissue, including muscle
Among synthetic small-molecule inhibitors, mechanisms are well-defined and inhibitory potency is strong, but limited bloodbrain barrier penetration and potential toxicity remain major obstacles to clinical translation
A review of six clinical trials (711 patients) suggested its ability to shield the nerves against toxic glucose levels and reduce pain in people with diabetes
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