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All participants followed a hypocaloric dietary regimen, reducing their daily caloric intake by 20%, based on age, along with a daily physical activity regimen consisting of a 20-min brisk walk
Preclinical studies have shown that GLP-1 receptor agonism can attenuate alcohol-induced locomotor stimulation and accumbal dopamine release, reduce nicotine-associated reward behaviors, and suppress cocaine seeking or self-administration in rodent models [18-21]
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