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NAC at doses above 1800mg daily has been associated with gastrointestinal discomfort in some individuals

In cells with intact KEAP1-NRF2 system, transiently stabilized NRF2 induces transcriptional activation of genes encoding xCT, SLC7A11 , and two subunits of gamma-glutamylcysteine ligase (GCL), GCLC and GCLM , in response to oxidative and electrophilic stresses

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Mercaptoacetic acid was dimerized in the presence of trifluoroacetic acid and acetone and then reduced with lithium aluminum hydride into the linker 2,2-(propane-2,2-diylbis(sulfanediyl))diacetic acid (synthetic strategy: Supplementary Fig