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factors such as hormonal imbalances, metabolism, stress, obesity, sleep quality, and underlying health conditions can contribute to stalled progress
Separately, misfolded or aggregated proteins in the cytosol participate in stress granule formation
96,97 Moreover, the ME1 protein is hypophosphorylated at S336 and hyperacetylated at K337 by PGAM family member 5 and acetyl-CoA acetyltransferase, respectively, resulting in ME1 translocation from mitochondria to the cytosol, dimerization and activation, thus strongly promoting NADPH generation and tumorigenesis
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