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Smith LJ, Shamsuddin M, Sporn PH, Denenberg M, Anderson J: Reduced superoxide dismutase in lung cells of patients with asthma

As anticipated, compared to the TDC group, the ASD group showed overall lower scores (indicative of worse symptoms) in adaptive behavior ratings (Global Adaptive Composite, GAC scores) (p 0.05)

Intracellular glutathione in lymphocytes showed no measurable increase

Although the mechanism(s) underlying NASH progression remain to be fully elucidated, accumulating evidence suggests that both oxidative stress and the pro-inflammatory cytokine tumor necrosis factor- (TNF) are critical contributors in this process 5