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However, dehydration can occur indirectly as a secondary consequence of common gastrointestinal side effects, such as nausea, vomiting, or diarrhea, alongside a significantly reduced drive to drink fluids due to profound appetite suppression

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33 Tirzepatide Tirzepatide (a dual glucose-dependent insulinotropic peptide and GLP-1 receptor agonist) safety was evaluated in a meta-regression study that established individual adverse event rates at weekly doses of 5, 10 and 15 mg