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Dysfunctional mitochondria in neutrophils, macrophages, and T lymphocytes alter cytokine production, phagocytic activity, and antigen presentation, tipping the balance toward excessive inflammation or postoperative immunosuppression, thereby exacerbating organ injury
Conversely, patients without those signals might avoid unnecessary interventions
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SIRT1 also inactivates p53 which is involved in neuronal cell death (Kim et al
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