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These findings not only enrich the molecular understanding of senescent cell clearance but also provide a novel strategy for precise targeting of endothelial cell senescence in therapeutic applications
doi: 10.1016/j.envres.2022.113492 96 KronborgTMHansenJFRasmussenKVorkampKNielsenCHFrederiksenMet al
Nevertheless, challenges persist owing to the non-specificity of Kla-associated enzymes, cellular heterogeneity within TME subsets, and unresolved safety profiles of metabolic inhibitors
Picomolar to nanomolar activity suggests high receptor affinity and potent biological signalling, which is encouraging for topical delivery where only a fraction of applied compound reaches the follicle
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