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The exacerbation of DR during puberty and pregnancy can be partially explained by the upregulation of VEGF and Ang-2, mediated by IGF-1 [14, 15, 27, 28], estrogen and progesterone [91, 92], in addition to hyperinsulinemia observed in both conditions
10.1046/j.1365-4362.2002.01423.x Int J Dermatol
Major points for thoroughness though- I have the sense that if I ever have a question on future about diabetes the answer can be found here...though not necessarily very easily
ClinicalTrials.gov identifier: NCT04788511
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