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In PCOS, oxidative stress contributes to: Hormonal disruption Insulin resistance Inflammation Poor skin recovery Pigmentation flare-ups Glutathione helps by: Reducing free radical damage Supporting cellular repair Calming stress-driven melanin activity This is why skin issues in PCOS often improve after internal balance improves , not before
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Furthermore, the GLS2 gene promoter contains a p53 consensus DNA-binding element whose expression was induced in response to oxidative stress [1, 46]
Chalkidou A, Simeonidis K, Angelakeris M, Samaras T, Martinez-Boubeta C, Balcells L, Papazisis K, Dendrinou-Samara C, Kalogirou O (2011) In vitro application of Fe/MgO nanoparticles as magnetically mediated hyperthermia agents for cancer treatment
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