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Methods A systematic literature search was conducted in PubMed, Web of Science, and Scopus until October 2022

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Its molecular structure and proposed mechanisms of action are what make it so intriguing to the scientific community

Putative molecular events include AMPK phosphorylation at Thr172, which may directly activate PGC-1 by phosphorylating Ser571, thereby upregulating mitochondrial transcription factors (NRF1, TFAM)

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