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45,46 In contrast, anorexigenic neurons suppress appetite by expressing proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) peptide

Convenience drives research into transdermal patches, sublingual formulations, and improved oral delivery systems

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Therefore, they are nowadays recommended as first line therapy in patients with T2DM and atherosclerotic cardiovascular disease to reduce events, regardless of baseline or target HbA1c and concomitant glucose-lowering medication according to the 2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes [31]