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The gastrointestinal side effects of Zepbound stem from its mechanism as a GIP/GLP-1 receptor agonist, which slows gastric emptying and alters bowel motility
The glucagonostatic effect of GLP-1(736) that remains in the presence of exendin(939) could be abolished by the DPP-4 inhibitor sitagliptin [32] (ESM Fig
How does oral semaglutide help with hunger
The published case literature supports this, showing that most patients who continued tirzepatide through mild to moderate injection site reactions experienced gradual improvement without needing to discontinue
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