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The liver detoxifies xenobiotics and endogenous waste products through conjugation reactions, but fat metabolism (lipolysis and beta-oxidation) is regulated by insulin, glucagon, epinephrine, and adipose tissue lipase activity

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NF-B activation upregulates genes involved in cell survival and proliferation, such as PUMA, leading to epithelial cell apoptosis and contributing to UC development ( 3 Components of oxidative stress and their contributions to IBD pathogenesis 3.1 ROS in IBD pathogenesis The superoxide anion (O2), which is produced when molecular oxygen gains one electron, is the most prevalent free radical in human tissues ( NOX1 p