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This is where I think the best path forward is to present several theories, which Im listing roughly from plausible to speculative
Two major neuronal populations present in the arcuate nucleus control caloric intake and energy expenditure: one population co-expresses orexigenic agouti-related peptide (AgRP) and neuropeptide Y and the other expresses the anorexigenic anorectic neuropeptides proopiomelanocortin and cocaine- and amphetamine-regulated transcript (POMC/CART)
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People taking a drug can report trends that do not emerge in short studies
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