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To generate C/EBP-deficient (C/EBP-/-) mice, we crossed the C/EBP-floxed mice with the CAG-CreERT 2 strain

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Thus we proposed the central idea of our commentary: Chronic glucagon suppression may shift amino-acid handling toward muscle proteolysis, creating a silent but progressive erosion of muscle reserve

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doi: 10.1016/j.cell.2007.08.036

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Weight loss itself also affects cardiovascular function

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