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The composition of the gut microbiota depends on many factors, such as the gastrointestinal region, host genetics, nutrition and health status, dietary habits, and the use of antibiotics
Results and discussion Peptide-oligourea hybrids design and functional assay Our peptideoligourea hybrids design started with GLP-1-NH 2 and the introduction of a glycine in position 2 of GLP-1 instead of alanine (GLP-1-G 2 , 1 ) as it is known to prevent DPP-4 degradation 31,32,33
The mechanisms are not fully understood but may involve delayed gastric emptying, activation of the area postrema in the central nervous system, changes in nutrient absorption, and altered intestinal motility [116,117,118]
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