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McCrimmon RJ, Catarig AM, Frias JP, et al

Why the Gap Matters The gap exists to protect you from an accidental stacking effect

Seek medical advice if you experience severe or persistent nausea and vomiting that prevents adequate fluid intake, signs of pancreatitis (severe abdominal pain radiating to the back), symptoms of thyroid tumors (neck mass, difficulty swallowing, persistent hoarseness), or signs of acute kidney injury (decreased urination, swelling)

People with significant weight to lose For individuals starting at a higher body weight, say 300 pounds or more, the absolute pounds lost with each medication become dramatic