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Research suggests it encourages the breakdown of stored fat without significantly affecting blood sugar or acting through the IGF-1 pathway

Many medical experts have warned against that recommendation, citing a lack of evidence

Vitamin B12 deficiency is the dominant nutritional cause of hyperhomocysteinemia in a folic acid-fortified population

avoidance recommended as a precaution Active malignancy: Pro-angiogenic mechanism warrants caution until more data is available History of hormone-sensitive cancers: Discuss thoroughly with your physician Severe coagulation disorders: Given vascular effects, clinical assessment required Patients on certain anticoagulants: Monitoring required