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Blandino-Rosano M, Scheys JO, Werneck-de-Castro JP, Louzada RA, Almaca J, Leibowitz G, Ruegg MA, Hall MN, Bernal-Mizrachi E

In research settings, Melanotan I is of interest due to its interaction with melanocortin receptors, particularly pathways associated with melanin production, pigmentation biology, and cellular responses linked to UV exposure

The study uses structural biophysics-guided computational methods to engineer site-specific missense mutations into the semaglutide peptide backbone, thereby increasing its binding affinity to the extracellular domain (ECD) of GLP-1R