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The combination group included those who added a newer generation GLP-1RA (i.e., exenatide once weekly [OW], dulaglutide, semaglutide OW T2D, or oral semaglutide) or dual GLP-1/GIP agonist (tirzepatide T2D) to their SGLT2i (i.e., canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, or bexagliflozin) treatment, with persistent use of a GLP-1RA and SGLT2i for 180 days each and an overlap 120 days, where the gap after exhaustion of days supply was required to be 30 days
For instance, semaglutide and liraglutide, two GLP-1RA agonist drugs, have been associated with weight loss and body weight maintenance (1012)
That review also suggests that the weight loss effects may be short-lived due to the way these drugs work
In PTC tumors, the BRAF V600 E mutation has been shown to be positively correlated with mTOR pathway activation and upregulation 21
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