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These symptoms often improve with continued treatment, but persistent or bothersome palpitations warrant clinical evaluation to exclude other causes and assess whether the heart rate increase is excessive

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This Fc domain serves a dual function: it sterically hinders access to DPP-4, thereby protecting the GLP-1 moiety from enzymatic degradation, and it engages the neonatal Fc receptor (FcRn), facilitating receptor-mediated recycling and preventing lysosomal degradation following cellular uptake

Reshma Ramachandran, a Yale medical school professor and the new study's senior author, told the Washington Post