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from foreign sources, endangering patient safety The Partnership for Safe Medicines today released a new report that found suspicious, unauthorized, and illegal ingredients for popular diabetes and obesity injectables (commonly known as weight loss drugs) are flooding into the U.S
Reported side effects include increased blood pressure, increased heart rate and even heart attacks
The general rule: Pause less than 2 weeks: restart at the same dose Pause 2 to 4 weeks: consider stepping down one dose level (e.g., 10 mg back to 7.5 mg) for the first few injections Pause more than 4 weeks: restart at the lowest dose (2.5 mg) and re-titrate, or at most 5 mg if you previously tolerated maintenance well The reason is that GLP-1 receptor sensitivity adjusts during the off period
POLG mutation screening should be performed in accordance with current clinical practice [seeWarnings and Precautions (5.1)]
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