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In the case of glucocorticoids, both excess (Cushings syndrome) and insufficiency (Addisons disease) contribute to oxidative stress through a variety of mechanisms, such as decreased antioxidant defenses, increased reactive oxygen species (ROS) generation, and impaired mitochondrial function, which ultimately results in chronic inflammation

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On average, research shows a 5% reduction in starting body weight after 12 weeks, with continued weight loss over six months to a year

GLP-1 acts primarily on the hypothalamic arcuate nucleus (POMC/NPY neurons) to regulate energy homeostasis and metabolic set-pointit's the 'background thermostat' for caloric balance