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Although some of the metabolic benefits conferred by bariatric surgeries have been ascribed to changes in the secretory profiles of various gut hormones, the therapeutic potential of the enteroendocrine system as a viable target against metabolic diseases remain largely underexploited, except for incretin-mimetics

Hormonal shifts during perimenopause and menopause often increase visceral fat, worsen insulin resistance, and amplify inflammatory pathways

Depending on a persons situation, strenuous exercise may not be possible or feasible

For patients without coverage, the decision comes down to a combination of clinical fit and budget