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Its elevation suggests changes in glutathione synthesis or utilization, although elevated urinary levels of pyroglutamic acid are often associated with glutathione depletion, some studies suggest that, under certain conditions characterized by increased oxidative stresssuch as sepsishigher urinary pyroglutamate was not correlated with worse clinical outcomes 66
The 50-64 age group is the most likely to have used these medications to treat chronic conditions (9%), while 5% of this group had used them for weight loss, and another 5% had used them for both chronic conditions and weight loss
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