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As of late 2021, available evidence suggests first-line therapy with SGLT2 inhibitors may improve some outcomes, particularly in individuals with newly diagnosed diabetes and comorbid heart and kidney health concerns
doi: 10.1016/j.yfrne.2014.04.004 5 TuressonCOFallonWMCrowsonCSGabrielSEMattesonEL
Immunogenicity associated with metreleptin treatment in patients with obesity or lipodystrophy
The specific antisense sequences were 5-GGCUCCUACACUUCUGUUATT-3 for FoxO4 siRNA and 5-UAACAGAAGUGUAGGAGCCTT-3 for the negative control
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