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Save flow-through and wash fractions if capture efficiency matters
19 Mechanistically, this vesicular cargo acts through the glutamine-fructose-6-phosphate transaminase 1 (GFPT1)-hexosamine biosynthesis pathway and transcriptional regulator BTB and CNC homolog 2 (BACH2)-dependent repression of the SLC7A11-GPX4 axis, thereby lowering the ferroptotic threshold of adjacent cells
The early PK studies ran for single administrations or short repeated-dose periods
Metabolic Safety Unlike full hGH, does not cause hyperglycemia, reduce insulin secretion, or increase insulin resistance
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