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Prolonged continuous use without an off period raises a theoretical risk of copper accumulation
Any Vitamin B12 that is not required by the body is excreted in the urine
Occasionally, some people notice mild, body-wide effects in the first day or so: Mild diarrhea or an upset stomach
Hydroxocobalamin may also be given intravenously in certain scenarios (for example, 5 g IV for acute cyanide poisoning antidote therapy), but such high-dose use is in emergency settings and distinct from routine deficiency treatment
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