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The risk of persistent glycemic disorders and SID increases with long-term or high-dose GCs use, mainly in oncological patients and patients treated for rheumatic and connective tissue disorders (25)

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It may support collagen synthesis, which is crucial for maintaining skin firmness and elasticity and reducing sagging

Taken together, the data in the literature indicate that GLP-1R signaling in ARC may be a major contributor to the homeostatic effects of GLP-1 analogs on feeding, whereas other brain regions such as the brainstem may play a minor role

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