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By performing microarray gene expression analysis in -cells isolated from 60-week-old mice, we found that MOTS-c downregulates genes related to mTOR pathway ( Cd38 , Camk2a , Map2k6 , Gck , and Ulk4 ) 71,93,94,95 and serine/threonine protein kinase ( Ripk1 , Styx , Wnk1 , Mapkapk3 and Ptk2b ), which regulates protein phosphorylation (Fig
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Switching, rather than combining, is a different clinical question
Although it was previously established that SmTrx will alter the observed reoxidation of the U597C SmTGR variant, impacting the first observed flavin reoxidation phase rate and ultimately eliminating the second reoxidation phase at higher Trx concentrations (Smith et al., 2023), it was not hitherto established whether the C154-C159 or the C596-U597 disulfides act to donate electrons to this oxidant
