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As the field evolves, its crucial for healthcare leaders and organizations to stay agile, adapt to new trends, and focus on what matters most for patients and providers, namely: GLP1s are now firstline therapies: Adoption has accelerated from just 3% in 2021 to more than 23% in 2025, displacing longstanding generics like metformin

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While calcium responses to the first on step were identical in both protocols, the amplitude of the second pulse, following a short offstep interval, was lower (Fig 6C), in agreement with the experimental results (Fig 4A)