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Using compounded GLP-1 drugs for off-label weight loss exposes providers to legal risks, including FDA and intellectual property penalties

The short answer The paper analysed 27,885 people who reported using semaglutide or tirzepatide-based drugs and found a significant association between a GLP1R variant and greater weight-loss efficacy, roughly 0.76 kg more weight loss per effect allele

This synergistic effect on blood sugar can push glucose levels too low, leading to hypoglycemia

Comparison of weight loss effects among overweight/obese adults: a network meta-analysis of Mediterranean, low carbohydrate, and low-fat diets