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The largest of these (still fairly small, n=159) was a randomized and controlled clinical trial published in the New England Journal of Medicine , and found that a dose of 100 mcg twice per day improved quality of life, reduced eye involvement, and slowed disease progression among participants with mild Graves' orbitopathy (compared to pentoxifylline or placebo)

Delayed gastric emptying increases the risk of regurgitation and aspiration pneumonia during induction of anesthesia, an especially concerning event in unconscious patients

GLP-1 receptor agonists are recommended by NICE when BMI is 35 kg/m (or lower in people of Black African, African-Caribbean, or South Asian family origin) or for whom weight loss would benefit obesity-related comorbidities