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Discontinuation in trials: retatrutide trial discontinuation due to adverse events was 6-10% across the higher-dose arms meaningful but lower than the dose-related side-effect profile would suggest, which indicates most participants tolerated the protocol

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In seven out of these nine studies with an elevated Glx/NAA the findings were a result of significant increases (52, 56, 57) in Glx, or non-significant changes (55) in Glx or glutamate, in conjunction with significant decreases in NAA in ALS patients relative to healthy controls