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Routine monitoring of serum calcitonin or using thyroid ultrasound is of uncertain value for early detection of MTC in patients treated with RYBELSUS Contraindications RYBELSUS is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), and in patients with a prior serious hypersensitivity reaction to semaglutide or to any of the excipients in RYBELSUS

The search also included abstracts published in the last American Diabetes Association (ADA) Scientific Sessions

Endocrine Alterations in Prader-Willi Syndrome The mechanism underlying abnormal hyperphagia in PWS is not fully understood