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The STEP 4 trial showed participants regaining approximately two-thirds of lost weight within one year of stopping medication

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For instance, numerous semaglutide trials in diabetic cohorts utilized the 1.0 mg dosage rather than the 2.4 mg dosage approved for obesity, inherently skewing relative efficacy assessments ( Both therapies exhibit favorable and comparable safety profiles, primarily characterized by transient gastrointestinal adverse events (29)

4 This exceeded the results of the STEP clinical trials, suggesting that comprehensive behavioural support may enhance medication outcomes